In the first study, Valeriya Lyssenko, MD, of Lund University, in Sweden, and her colleagues tested 16,061 Swedes and 2,770 Finns for 16 gene variants. They found that 11 of them were linked to an increased risk of type 2 diabetes.
In the second study, James B. Meigs, MD, of Massachusetts General Hospital, in Boston, and his team looked at 18 gene variants in 2,377 men and women. The chances of developing type 2 diabetes rose with the number of these variants.
But the data gleaned from the genes provides little new information about risk. In Dr. Meigs’s study, in which participants were classified into three risk groups, the addition of genetic risk to the equation would, at most, have resulted in 4% of patients being reclassified as being at higher risk.
For the Scandinavian research team, adding genetic risk factors to the mix moved 9% of the Swedish group and 20% of the Finnish group into a higher-risk category. The researchers did take a closer look at what the genetic variants were doing in the body, and found that “all of them influence the capacity of insulin-producing beta-cells to increase insulin secretion when needed, for example, during pregnancy or when getting obese or old,” Dr. Lyssenko says.
For now, the studies seem to have little application in the real world. The findings are “too premature” to help individual people figure out their own risk, according to Dr. Lyssenko.
However, Dr. Hellman still sees it as good news for patients. “It says that there’s much more that we can do to change the course,” he says. “It isn’t just, ‘This is your genotype and this is your destiny.’”
Dr. Lyssenko agrees. “We may not be able to change our genes, but genes only work in concert with the environment, and we can change the environment; we can still improve our future by healthy diet and exercise.”
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Comments (3)
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Very interesting. Isn’t predicting diabetes one of the most important parts of genomic sequencing? We are always interested in the latest DNA news.
Please talk with a registered dceaiiitn (R.D.) about the proper nutritents to consume. Some RD’s are also called Certified Diabetes Educators (CDE) and are experts, in a sense, on the proper nutrition for someone with diabetes. You may be able to find such a dceaiiitn at your local hospital. My father has Type I diabetes (now uses an insulin pump) which used to be referred to as juvenile diabetes and along with keeping a close watch on his dietary intake, and checking his blood sugar 4x a day per his endrocrinologist (dr. who specializes in those with metabolic disorders including diabetes), he keeps excellent records of his blood sugar each day as well as his insulin needs for when he has to go to the dr.